Products for Research Use Only
RegisterLogin

CXCR4 Antibody

CAT: 0800-R31192Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R31192Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Chemokine, CXC Motif, Receptor 4, also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. By PCR analysis of human/hamster hybrid cell DNA, Herzog et al. (1993) showed that the NPY3R gene is located on human chromosome 2. Feng et al. (1996) showed that transient expression of the gene allowed nonhuman cells coexpressing recombinant CD4 to undergo Env-CD4-mediated cell fusion and productive HIV-1 infection. Peled et al. (1999) demonstrated that SDF1 and its receptor CXCR4 are critical for murine bone marrow engraftment by human SCID repopulating stem cells. Treatment of human cells with anti-CXCR antibodies prevented engraftment.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P61073
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 31-43 (EENANFNKIFLPT) were used as the immunogen for this CXCR4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CXCR4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CXCR4 antibody is available for research use only.
Storage Conditions
After reconstitution, the CXCR4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Titration of the CXCR4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CXCR4 antibody; Lane 1: M231; 2: MCF-7; 3: Jurkat cell lysate. Predicted molecular weight ~40 kDa but may be observed at higher molecular weights due to glycosylation.

UniProtKB · P61073

C-X-C chemokine receptor type 4

CXCR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61073
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCR4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CXC-R4, CXCR-4
EC number
—
Processing
—
Secondary accessions
B2R5N0, O60835, P30991, P56438, Q53S69, Q9BXA0, Q9UKN2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneEndosomeLysosomeMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

G protein-coupled receptorHost cell receptor for virus entryReceptorTransducer

Biological process

Host-virus interaction

Domain

TransmembraneTransmembrane helix

Related Products

CatalogName
R31194CXCR6 Antibody
R35867-100UGCXCR6 Antibody
RQ7070Cxcr3 Antibody
R30518CXCL4 Antibody
RQ5809CXCR2 Antibody
R31193CXCR6 Antibody
R31191CXCR1 Antibody
R33768-100UGCxcr2 Antibody
RQ5688CXCR2 Antibody
F40514-0.4MLCXCR3 Antibody

Alternative Products

CatalogName
70R-7849CXCR4 antibody

Popular Products