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ALDH2 Antibody

CAT: 0800-R31184Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31184Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aldehyde Dehydrogenase 2 is a human gene. The enzyme encoded by this gene belongs to the ALDH family of enzymes that catalyze the chemical transformation from acetaldehyde to acetic acid. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Hsu et al. (1985) assigned the ALDH2 locus to chromosome 12 by means of a cDNA probe and Southern blot analysis of somatic cell hybrids. Using an unbiased proteomic search, Chen et al. (2008) identified mitochondrial ALDH2 as an enzyme whose activation correlated with reduced ischemic heart damage in rodent models. A high-throughput screen identified a small molecule activator of ALDH2, which they called Alda-1, that, when administered to rats before an ischemic event, reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P05091
Host
Rabbit
Reactivity
Human, Rat
Immunogen
An amino acid sequence from the N-terminus of human Aldehyde Dehydrogenase 2 (SAAATQAVPAPNQQPE) was used as the immunogen for this ALDH2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the ALDH2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ALDH2 antibody is available for research use only.
Storage Conditions
After reconstitution, the ALDH2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the ALDH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of ALDH2 antibody and rat samples; Lane 1: liver; 2: intestine; 3: lung; 4: kidney tissue lysate. Predicted molecular weight: ~56kDa.

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