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CYP2U1 Antibody

CAT: 0800-R31130Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31130Size:100 µg
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Description
Cytochrome P450, Family 2, Subfamily U, Polypeptide 1 is a protein that in humans is encoded by the CYP2U1 gene. Members of the P450 enzyme family have roles in the tissue-specific conversion of substrates into locally active hormones, vitamins, and signaling molecules, including arachidonic acid derivatives known as eicosanoids. The International Radiation Hybrid Mapping Consortium mapped the gene to chromosome 4.Chuang et al. (2004) stated that CYP2U1 maps to 4q25. Using recombination experiments in Sf9 insect cells, Chuang et al. (2004) found that CYP2U1 metabolized arachidonic acid, docosahexaenoic acid (DHA), and other long chain fatty acids. Chuang et al. (2004) suggested that CYP2U1 may play a role in brain and immune functions.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, Immunocytochemistry: 0.5-1 µg/mL
UniProt
Q7Z449
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the C-terminus of human Cytochrome P450, Family 2, Subfamily U, Polypeptide 1 (EKPEDFYPNRFLDDQGQ) was used as the immunogen for this CYP2U1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CYP2U1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CYP2U1 antibody is available for research use only.
Storage Conditions
After reconstitution, the CYP2U1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CYP2U1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CYP2U1 antibody and Lane 1: HeLa; 2: MCF-7; 3: MM453; 4: COLO320; 5: HT1080 cell lysate

UniProtKB · Q7Z449

Cytochrome P450 2U1

CP2U1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q7Z449
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP2U1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RMV7, Q96EQ6
Protein keywords

Coding sequence diversity

Alternative splicing

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantHereditary spastic paraplegiaNeurodegeneration

Cellular component

Endoplasmic reticulumMembraneMicrosomeMitochondrionMitochondrion inner membrane

Ligand

HemeIronMetal-binding

Biological process

Lipid metabolism

Molecular function

MonooxygenaseOxidoreductase

Domain

TransmembraneTransmembrane helix

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