JNK1 Antibody

CAT: 0800-R30992Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-R30992Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Mitogen-activated protein kinase 8, also known as JNK1, PRKM8, and SAPK1, is an enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase and JNK family. The International Radiation Hybrid Mapping Consortium mapped the MAPK8 gene to chromosome 10. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. This kinase is also involved in UV radiation-induced apoptosis, which is though to be related to the cytochrome c-mediated cell death pathway.

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

P45983

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

An amino acid sequence from the N-terminus of human JNK1 (MSRSKRDNNFYSVEI) was used as the immunogen for this JNK1 antibody (100% homologous in human, mouse and rat) .

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal

Reconstitution

After reconstitution, the JNK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This JNK1 antibody is available for research use only.

Storage Conditions

After reconstitution, the JNK1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the JNK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of JNK1 antibody and HT1080 cell lysate. Expected size: 42KD

UniProtKB · P45983

Mitogen-activated protein kinase 8

MK08_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P45983
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MAPK8
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: MAP kinase 8, MAPK 8
EC number: 2.7.11.24
Processing: —
Secondary accessions: B5BTZ5, B7ZLV4, D3DX88, D3DX92, Q15709, Q15712, Q15713, Q308M2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Biological rhythms

Cellular component

CytoplasmNucleusSynapse

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinS-nitrosylation

Product Datasheet

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Alternative Products

Catalog	Name
DF2356-01	JNK1 Antibody