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JNK Antibody / MAPK8

CAT: 0800-F50464-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F50464-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin) : 1:10-1:50
UniProt
P45983
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 358-389 from the human protein was used as the immunogen for this JNK antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the JNK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This JNK antibody is available for research use only.
Storage Conditions
Aliquot the JNK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the JNK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Rat
Image Legend
JNK1 antibody immunohsitochemistry analysis in formalin fixed and paraffin embedded human breast tissue.
Product Datasheet
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