NOTCH4 Antibody

NOTCH4 Antibody

• Description: NOTCH4 is a member of the Notch family. In situ hybridization revealed that Notch4 transcripts are primarily restricted to endothelial cells in embryonic and adult life, suggesting a specific role for the protein during development of vertebrate endothelium. The sequences of the mouse and human proteins are 82% identical. Northern blot analysis revealed that NOTCH4(S) is the major transcript and is expressed in a wide variety of tissues. Fluorescence in situ hybridization confirmed the location of the gene at chromosome 6p21.3. In linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios, Wei and Hemmings(2000) found that NOTCH4 was highly associated with schizophrenia. Repression of Notch4 resolved ataxia and reversed the disease progression, demonstrating that it is not only sufficient to induce but also required to sustain the disease.
• CAS Number: 9007-83-4
• UniProt: Q99466
• Host: Rabbit
• Immunogen: An amino acid sequence from the C-terminus of human NOTCH4 (DVAHQRNHWDLLTL) was used as the immunogen for this NOTCH4 antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the NOTCH4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This NOTCH4 antibody is available for research use only.