NOTCH3 Antibody

CAT: 0800-F49506-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F49506-0.4MLSize:0.4 mL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin) : 1:50-1:100
UniProt
Q9UM47
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 2291-2321 from the human protein was used as the immunogen for this NOTCH3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NOTCH3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NOTCH3 antibody is available for research use only.
Storage Conditions
Aliquot the NOTCH3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NOTCH3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Confocal immunofluorescent analysis of NOTCH3 antibody with HepG2 cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) . DAPI was used as a nuclear counterstain (blue) .

Related Products

CatalogName
R30929NOTCH4 Antibody
RQ6458NOTCH1 Antibody
R30316NOTCH1 Antibody
F53420-0.4MLNOTCH4 Antibody
F53420-0.08MLNOTCH4 Antibody
F53342-0.08MLNotch1 Antibody
F53342-0.4MLNotch1 Antibody
RQ5542NOTCH2 Antibody
F53063-0.08MLNOTCH Antibody
F53063-0.4MLNOTCH Antibody

Alternative Products

CatalogName
MBS8502602-01NOTCH3 Antibody

Popular Products