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NOTCH1 Antibody

CAT: 0800-R30316Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30316Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P46531
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human NOTCH1 (QHSYSSPVDNTPSHQLQVPE) was used as the immunogen for this NOTCH1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Notch1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This NOTCH1 antibody is available for research use only.
Storage Conditions
After reconstitution, the NOTCH1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the NOTCH1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of NOTCH1 antibody and Lane 1: MCF-7; 2: HeLa; 3: Jurkat; 4: COLO320. Predicted molecular weight: ~ 270 kDa (full length), ~ 120 kDa (transmembrane fragment) .

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