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PAK6 Antibody

CAT: 0800-R30819Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30819Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P21 protein-activated kinase 6 is an enzyme that in humans is encoded by the PAK6 gene. This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q9NQU5
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
An amino acid sequence from the N-terminus of human PAK6 (QNFQHRVHTSFDPKEGK) was used as the immunogen for this PAK6 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the PAK6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PAK6 antibody is available for research use only.
Storage Conditions
After reconstitution, the PAK6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the PAK6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of PAK6 antibody and Lane 1: HeLa; 2: 293T; 3: Raji; 4: COLO320 cell lysate

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