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FGF19 Antibody

CAT: 0800-R30548Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30548Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL
UniProt
O95750
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of the human protein (EEIRPDGYNVYRSEKHR) was used as the immunogen for this FGF19 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the FGF19 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This FGF19 antibody is available for research use only.
Storage Conditions
After reconstitution, the FGF19 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the FGF19 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, secreted
Image Legend
Western blot testing of FGF19 antibody and Lane 1: rat brain; 2: human U87; 3: human SMMC-7721 cell lysate. Predicted molecular weight ~24 kDa.

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