TIMP4 Antibody

• Description:

  The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. The TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.

• Specifications:

  Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL

• UniProt:

  Q99727

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Amino acids 208-224 (YRGHLPLRKEFVDIVQP-human) were used as the immunogen for this TIMP4 antibody.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  WB, IHC-P

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  0.5mg/ml if reconstituted with 0.2ml sterile DI water

• Reconstitution:

  Store the TIMP4 antibody at -20oC.

• Limitations:

  This TIMP4 antibody is available for research use only.

• Storage Conditions:

  Store the TIMP4 antibody at -20°C.

• Formulation:

  0.5 mg/mL if reconstituted with 0.2ml sterile DI water

• Applications Notes:

  The stated application concentrations are suggested starting amounts. Titration of the TIMP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Location:

  Secreted

• Image Legend:

  Western blot testing of TIMP4 antibody and Lane 1: rat kidney; 2: human MCF-7; Predicted/observed molecular weight: ~25 kDa.