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ALDH6A1 Antibody

CAT: 0800-F54378-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54378-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALDH6A1 belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. This protein is a mitochondrial methylmalonate semialdehyde dehydrogenase, and catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000, Flow cytometry: 1:25 (1x10e6 cells)
UniProt
Q02252
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 30-59 from the human protein was used as the immunogen for the ALDH6A1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, WB, FACS
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ALDH6A1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ALDH6A1 antibody is available for research use only.
Storage Conditions
Aliquot the ALDH6A1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the ALDH6A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of human T-47D cell lysate with ALDH6A1 antibody. Predicted molecular weight: ~58 kDa.

UniProtKB · Q02252

Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

MMSA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q02252
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALDH6A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MMSDH
EC number
1.2.1.27
Processing
Precursor
Secondary accessions
B2R609, B4DFS8, J3KNU8, Q9UKM8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Cellular component

Mitochondrion

Ligand

NAD

Molecular function

Oxidoreductase

Domain

Transit peptide

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