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ALDH5A1 Antibody

CAT: 0800-F54698-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54698-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALDH5A1 belongs to the aldehyde dehydrogenase family of proteins. This protein functions as a mitochondrial NAD (+) -dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA) . In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
P51649
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 128-157 from the human protein was used as the immunogen for the ALDH5A1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, WB
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ALDH5A1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ALDH5A1 antibody is available for research use only.
Storage Conditions
Aliquot the ALDH5A1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the ALDH5A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) non-transfected and 2) transfected 293 cell lysate with ALDH5A1 antibody. Predicted molecular weight ~57 kDa.

UniProtKB · P51649

Succinate-semialdehyde dehydrogenase, mitochondrial

SSDH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51649
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALDH5A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.2.1.24
Processing
Precursor
Secondary accessions
B2RD26, G5E949, Q546H9, Q8N3W6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondPhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Cellular component

Mitochondrion

Ligand

NAD

Molecular function

Oxidoreductase

Domain

Transit peptide

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