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SIRT6 Antibody

CAT: 0800-F54008-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0800-F54008-0.1MLSize:0.1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:500, ICC/IF: 1:100, Immunoprecipitation: suitable
UniProt
Q8N6T7
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A human recombinant protein was used as the immunogen for this SIRT6 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
6C9-D10-D3
Applications
WB, ICC/IF, IP
Purity
Protein G affinity
Format
Purified
Buffer
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Reconstitution
Store the SIRT6 antibody at -20oC.
Limitations
This SIRT6 antibody is available for research use only.
Storage Conditions
Store the SIRT6 antibody at -20°C.
Formulation
In PBS with 50% glycerol and 0.03% ProClin 300
Applications Notes
The stated application concentrations are suggested starting points. Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human Jurkat, MCF7, HCT116, K562, monkey COS7, mouse C2C12, mouse NIH3T3 and human HeLa cell lysates using SIRT6 antibody at 1:500. Predicted molecular weight ~42 kDa.

UniProtKB · Q8N6T7

NAD-dependent protein deacylase sirtuin-6

SIR6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N6T7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIRT6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.-
Processing
—
Secondary accessions
B2RCD0, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

AcyltransferaseChromatin regulatorDevelopmental proteinDNA-bindingGlycosyltransferaseNucleotidyltransferaseRNA-bindingTransferase

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeEndoplasmic reticulumNucleusTelomere

Biological process

DNA damageDNA repair

Ligand

Metal-bindingNADZinc

Disease

Tumor suppressor

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