USP2 Antibody

CAT: 0800-F53953-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
CAT#:0800-F53953-0.05MLSize:0.05 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ubiquitin carboxyl-terminal hydrolase 2 is a hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity) .
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000
UniProt
O75604
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant protein corresponding to amino acids 1-258 from the human protein was used as the immunogen for the USP2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1738CT331.50.87
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the USP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This USP2 antibody is available for research use only.
Storage Conditions
Aliquot the USP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the USP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human 1) MCF-7, 2) PC-3, 3) COS-7, 4) DU-145 and 5) SK-BR-3 cell lysate with USP2 antibody at 1:2000. Predicted molecular weight: 68 kDa. Isoforms at ~41 and ~45 kDa may also be observed.
Product Datasheet
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