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AKT Antibody

CAT: 0800-F53789-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0800-F53789-0.1MLSize:0.1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I.
CAS Number
9007-83-4
Specifications
Western blot: 1:5000
UniProt
P31749
Host
Mouse
Reactivity
Human
Immunogen
This AKT antibody was produced from mice immunized with a KLH conjugated synthetic peptide selected from the 430-460 region of human AKT1.
Clonality
Monoclonal
Isotype
IgG1
Clone
960CT4.5.1
Applications
WB, ELISA
Purity
Ascites
Format
Ascites
Buffer
In ascites with 0.09% sodium azide
Reconstitution
Aliquot the AKT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This AKT antibody is available for research use only.
Storage Conditions
Aliquot the AKT antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In ascites with 0.09% sodium azide
Applications Notes
Titration of the AKT antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Mouse, Rat
Image Legend
AKT antibody western blot analysis in HL-60 lysate

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