Erbb2 Antibody

CAT: 0800-F53251-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F53251-0.08MLSize:0.08 mL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs) . Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity) .
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
P70424
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
This mouse Erbb2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1236-1268 amino acids from the mouse Erbb2.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the Erbb2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Erbb2 antibody is available for research use only.
Storage Conditions
Aliquot the Erbb2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Erbb2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Erbb2 antibody at 1:2000 dilution. Lane 1: mouse ovary lysate; 2: rat lung lysate; Predicted band size : 139 kDa.

Related Products

CatalogName
RQ5055HER2 Antibody / ErbB2
V7407-100UGHER2 Antibody / ErbB2
V2108SAF-100UGHER2 Antibody / ErbB2
V7735-100UGHER2 Antibody / ErbB2
V2378SAF-100UGHER2 Antibody ErbB2
V7736-20UGHER2 Antibody / ErbB2
V2108-100UGHER2 Antibody / ErbB2
V2108-20UGHER2 Antibody / ErbB2
V3838SAF-100UGHER2 Antibody / ErbB2
V3839-20UGHER2 Antibody / ErbB2

Alternative Products

CatalogName
MBS7119160-01ERBB2 Antibody

Popular Products