HER-2 Antibody

CAT: 0800-F52968-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F52968-0.4MLSize:0.4 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs) . Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P04626
Host
Mouse
Reactivity
Human
Immunogen
This HER-2 antibody was produced from a mouse immunized with a recombinant protein.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
1423CT594.76.52
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HER-2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HER-2 antibody is available for research use only.
Storage Conditions
Aliquot the HER-2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the HER-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from 1) MDA-MB-453 and 2) SK-BR-3 cell line using HER-2 antibody at 1:1000.
Product Datasheet
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