STAT3 Antibody

• Description:

  Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) - responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) .

• Specifications:

  Western blot: 1:1000

• UniProt:

  P40763

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  This STAT3 antibody was produced from a mouse immunized with a recombinant protein from human.

• Clonality:

  Monoclonal

• Isotype:

  IgG2a κ

• Clone:

  1200CT146.104.153

• Applications:

  WB, ELISA

• Purity:

  Purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the STAT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This STAT3 antibody is available for research use only.

• Storage Conditions:

  Aliquot the STAT3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the STAT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Prediction Reactivity:

  Mouse, Rat, Pig

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot analysis of lysate from CEM, HeLa cell line (left to right) using STAT3 antibody at 1:1000 for each lane.