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STAT1 Antibody

CAT: 0800-F52347-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F52347-0.08MLSize:0.08 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P42224
Host
Mouse
Reactivity
Human
Immunogen
Purified His-tagged protein was used to produced this monoclonal STAT1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
1141CT26.2.1
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the STAT1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This STAT1 antibody is available for research use only.
Storage Conditions
Aliquot the STAT1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the STAT1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
STAT1 antibody western blot analysis in (1) CEM and (2) HeLa lysate. Predicted molecular weight: ~91/84kDa (alpha/beta) .

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