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Phospho-ErbB2 Antibody (pY1222)

CAT: 0800-F52420-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F52420-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
CAS Number
9007-83-4
UniProt
P04626
Host
Rabbit
Immunogen
This phospho-ErbB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1222 of the human protein.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the phospho-ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This phospho-ErbB2 antibody is available for research use only.

UniProtKB · P04626

Receptor tyrosine-protein kinase erbB-2

ERBB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04626
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ERBB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B2RZG3, B4DHN3, Q14256, Q6LDV1, Q9UMK4, X5D2V5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorKinaseReceptorTransferaseTyrosine-protein kinase

Coding sequence diversity

Alternative initiationAlternative splicingChromosomal rearrangement

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionCytoplasmEndosomeMembraneNucleus

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

Biological process

TranscriptionTranscription regulation

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