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CYP1A1 Antibody

CAT: 0800-F50940-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50940-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYP1A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. CYP1A1 gene has been associated with lung cancer risk.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin) : 1:10-1:50
UniProt
P04798
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 252-280 from the human protein was used as the immunogen for this CYP1A1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CYP1A1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CYP1A1 antibody is available for research use only.
Storage Conditions
Aliquot the CYP1A1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CYP1A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, membrane
Image Legend
Confocal immunofluorescent analysis of CYP1A1 antibody with MDA-MB231 cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) . DAPI was used as a nuclear counterstain (blue) .

UniProtKB · P04798

Cytochrome P450 1A1

CP1A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04798
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CYPIA1
EC number
1.14.14.1
Processing
—
Secondary accessions
A4F3V9, A4F3W0, Q53G18
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndoplasmic reticulumMembraneMicrosomeMitochondrionMitochondrion inner membrane

Biological process

Fatty acid metabolismLipid biosynthesisLipid metabolismSteroid biosynthesis

PTM

Glycoprotein

Ligand

HemeIronMetal-binding

Molecular function

LyaseMonooxygenaseOxidoreductase

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