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CYP1A1/1A2 Antibody

CAT: 0800-V7709-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7709-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P04798
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
3-methylcholanthrene induced rat cytochrome P450 protein was used as the immunogen for the CYP1A1/1A2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MC1
Applications
IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CYP1A1/1A2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CYP1A1/1A2 antibody is available for research use only.
Storage Conditions
Store the CYP1A1/1A2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CYP1A1/1A2 antibody should be determined by the researcher.
Image Legend
SDS-PAGE analysis of purified, BSA-free CYP1A1/1A2 antibody (clone MC1) as confirmation of integrity and purity.

UniProtKB · P04798

Cytochrome P450 1A1

CP1A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04798
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CYPIA1
EC number
1.14.14.1
Processing
—
Secondary accessions
A4F3V9, A4F3W0, Q53G18
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndoplasmic reticulumMembraneMicrosomeMitochondrionMitochondrion inner membrane

Biological process

Fatty acid metabolismLipid biosynthesisLipid metabolismSteroid biosynthesis

PTM

Glycoprotein

Ligand

HemeIronMetal-binding

Molecular function

LyaseMonooxygenaseOxidoreductase

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