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TAK1 Antibody / MAP3K7

CAT: 0800-F50911-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F50911-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TAK1 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
O43318
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 574-606 from the human protein was used as the immunogen for this TAK1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TAK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TAK1 antibody is available for research use only.
Storage Conditions
Aliquot the TAK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TAK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Mouse, Rat
Image Legend
IHC analysis of FFPE human hepatocarcinoma tissue stained with the TAK1 antibody.

UniProtKB · O43318

Mitogen-activated protein kinase kinase kinase 7

M3K7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43318
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP3K7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
B2RE27, E1P523, O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3, Q9NZ70
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interactionStress responseTranscriptionTranscription regulation

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembrane

Disease

Disease variant

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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