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CYP1B1 Antibody

CAT: 0800-F50866-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50866-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYP1B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in CYP1B1 gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q16678
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 143-176 from the human protein was used as the immunogen for this CYP1B1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CYP1B1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CYP1B1 antibody is available for research use only.
Storage Conditions
Aliquot the CYP1B1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CYP1B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of CYP1B1 antibody and CEM lysate

UniProtKB · Q16678

Cytochrome P450 1B1

CP1B1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16678
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP1B1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.14.1
Processing
—
Secondary accessions
Q5TZW8, Q93089, Q9H316
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Disease

Disease variantGlaucomaPeters anomaly

Cellular component

Endoplasmic reticulumMembraneMicrosomeMitochondrion

Biological process

Fatty acid metabolismLipid metabolismSteroid metabolism

Ligand

HemeIronMetal-binding

Molecular function

LyaseMonooxygenaseOxidoreductase
Product Datasheet
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