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HIF-1 alpha Antibody

CAT: 0800-F50744-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F50744-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT) .
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin) : 1:10-1:50
UniProt
Q16665
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 728-757 from the human protein was used as the immunogen for this HIF-1 alpha antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, IF, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the HIF-1 alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HIF-1 alpha antibody is available for research use only.
Storage Conditions
Aliquot the HIF-1 alpha antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the HIF-1 alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear, possible cytoplasmic
Image Legend
Western blot analysis of HIF-1 alpha antibody and MDA-MB231 lysate. Routinely observed molecular weight: 100~120 kDa.

UniProtKB · Q16665

Hypoxia-inducible factor 1-alpha

HIF1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16665
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HIF1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HIF-1-alpha, HIF1-alpha
EC number
—
Processing
—
Secondary accessions
C0LZJ3, Q53XP6, Q96PT9, Q9UPB1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinHydroxylationIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

Host-virus interactionTranscriptionTranscription regulation

Domain

Repeat

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