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PDGFR beta Antibody (CD140b)

CAT: 0800-F50659-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50659-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses the gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia.
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:10-1:50, Immunofluorescence: 1:10-1:50, Flow Cytometry: 1:10-1:50, Western blot: 1:1000
UniProt
P09619
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 40-72 from the human protein was used as the immunogen for this CD140b / PDGFR beta antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, IF, FACS, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Store at 4oC for up to one month. For long term, aliquot the PDGFR beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PDGFR beta antibody is available for research use only.
Storage Conditions
Store at 4°C for up to one month. For long term, aliquot the PDGFR beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the PDGFR beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Flow cytometric analysis of SK-Br-3 cells using PDGFR beta antibody (bottom histogram) compared to a negative control (top histogram) . FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.

UniProtKB · P09619

Platelet-derived growth factor receptor beta

PGFRB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09619
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDGFRB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PDGF-R-beta, PDGFR-beta
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B5A957, Q8N5L4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmic vesicleLysosomeMembrane

Biological process

Chemotaxis

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variantProto-oncogene

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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