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PDGFR Antibody (CD140b)

CAT: 0800-F40302-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F40302-0.4MLSize:0.4 mL
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Description
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq].
CAS Number
9007-83-4
Specifications
Western blot: 1:8-1:30
UniProt
P09619
Host
Mouse
Reactivity
Mouse
Immunogen
This PDGFR antibody was produced from a mouse immunized with recombinant protein.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
275CT1
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PDGFR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PDGFR antibody is available for research use only.
Storage Conditions
Aliquot the PDGFR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PDGFR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
PDGFR antibody western blot analysis in mouse NIH3T3 lysate. Expected molecular weight: 123-190 kDa depending on level of glycosylation.

UniProtKB · P09619

Platelet-derived growth factor receptor beta

PGFRB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09619
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDGFRB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PDGF-R-beta, PDGFR-beta
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B5A957, Q8N5L4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmic vesicleLysosomeMembrane

Biological process

Chemotaxis

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variantProto-oncogene

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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