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Lamin A/C Antibody

CAT: 0800-RQ7653Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7653Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C is mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
P02545
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
E. coli-derived recombinant human protein (amino acids Y481-Y646) was used as the immunogen for the Lamin A/C antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
5F3C12
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Lamin A/C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Lamin A/C antibody is available for research use only.
Storage Conditions
After reconstitution, the Lamin A/C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Lamin A/C antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC staining of FFPE human laryngeal squamous cell carcinoma tissue with Lamin A/C antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · P02545

Prelamin-A/C

LMNA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02545
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LMNA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DI32, D3DVB0, D6RAQ3, E7EUI9, P02546, Q5I6Y4, Q5I6Y6, Q5TCJ2, Q5TCJ3, Q6UYC3, Q969I8, Q96JA2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondLipoproteinMethylationPhosphoproteinPrenylationUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyCharcot-Marie-Tooth diseaseCongenital muscular dystrophyDisease variantEmery-Dreifuss muscular dystrophyLimb-girdle muscular dystrophyNeurodegenerationNeuropathy

Domain

Coiled coil

Cellular component

Intermediate filamentNucleus

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