Products for Research Use Only

MMP7 Antibody

CAT: 0800-F49501-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F49501-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP7 degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100, Immunofluorescence: 1:10-1:50
UniProt
P09237
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 117-146 from the human protein was used as the immunogen for this MMP7 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, IF, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MMP7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MMP7 antibody is available for research use only.
Storage Conditions
Aliquot the MMP7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the MMP7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Confocal immunofluorescent analysis of MMP7 antibody with 293 cells followed by Alexa Fluor 488-conjugated goat rabbit lgG (green) . DAPI was used as a nuclear counterstain (blue) .

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