ATF6 beta Antibody

CAT: 0800-F49022-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F49022-0.4MLSize:0.4 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATF6 beta is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus.
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:25, Western blot: 1:1000
UniProt
Q99941
Host
Rabbit
Reactivity
Human, Hamster, Mouse
Immunogen
A portion of amino acids 560-589 from the human protein was used as the immunogen for this ATF6 beta antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ATF6 beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ATF6 beta antibody is available for research use only.
Storage Conditions
Aliquot the ATF6 beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ATF6 beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from (1) HeLa, (2) HepG2 and (3) human placenta tissue lysate using ATF6 beta antibody at 1:1000. Predicted molecular weight: 75~90kDa.
Product Datasheet
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