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P-Tuberin Antibody (pS939)

CAT: 0800-F48512-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F48512-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mutations in TSC2/Tuberin lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
CAS Number
9007-83-4
Specifications
Dot blot: 1:500, Immunofluorescence: 1:10-1:50
UniProt
P49815
Host
Rabbit
Reactivity
Human
Immunogen
This p-Tuberin antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS939 of human TSC2.
Clonality
Polyclonal
Isotype
Ig
Applications
DB, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the p-Tuberin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This p-Tuberin antibody is available for research use only.
Storage Conditions
Aliquot the p-Tuberin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the p-Tuberin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse
Image Legend
Confocal immunofluorescent analysis of p-Tuberin antibody with MCF-7 cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) . Actin filaments have been labeled with Alexa Fluor 555 Phalloidin (red) . DAPI was used as a nuclear counterstain (blue) .

UniProtKB · P49815

Tuberin

TSC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49815
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TSC2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A7E2E2, B4DIL8, B4DIQ7, B4DRN2, B7Z2B8, C9J378, O75275, Q4LE71, Q8TAZ1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmLysosomeMembrane

Disease

Disease variantEpilepsyTumor suppressor

Molecular function

GTPase activation

Biological process

Host-virus interaction

PTM

PhosphoproteinUbl conjugation
Product Datasheet
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