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CXCR4 Antibody

CAT: 0800-F47386-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F47386-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
CAS Number
9007-83-4
UniProt
P61073
Host
Rabbit
Immunogen
A portion of amino acids 50-79 from the human protein was used as the immunogen for this anti-CXCR4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the anti-CXCR4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This anti-CXCR4 antibody is available for research use only.

UniProtKB · P61073

C-X-C chemokine receptor type 4

CXCR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61073
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCR4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CXC-R4, CXCR-4
EC number
—
Processing
—
Secondary accessions
B2R5N0, O60835, P30991, P56438, Q53S69, Q9BXA0, Q9UKN2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneEndosomeLysosomeMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

G protein-coupled receptorHost cell receptor for virus entryReceptorTransducer

Biological process

Host-virus interaction

Domain

TransmembraneTransmembrane helix
Product Datasheet
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