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Cdkn2a Antibody

CAT: 0800-F47172-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F47172-0.08MLSize:0.08 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q64364
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 39-65 from the mouse protein was used as the immunogen for this Cdkn2a antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Cdkn2a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Cdkn2a antibody is available for research use only.
Storage Conditions
Aliquot the Cdkn2a antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Cdkn2a antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Cdkn2a antibody western blot analysis in mouse spleen tissue lysate.

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