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Alpha-2-macroglobulin Antibody

CAT: 0800-F44165-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F44165-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq].
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P01023
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 93-120 from the human protein was used as the immunogen for this Alpha-2-macroglobulin antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Alpha-2-macroglobulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Alpha-2-macroglobulin antibody is available for research use only.
Storage Conditions
Aliquot the Alpha-2-macroglobulin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Alpha-2-macroglobulin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine
Image Legend
Alpha-2-macroglobulin antibody western blot analysis in mouse plasma lysate. Predicted molecular weight: ~163/200kDa (unmodified/glycosylated) .

UniProtKB · P01023

Alpha-2-macroglobulin

A2MG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01023
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
A2M
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Alpha-2-M
EC number
—
Processing
Precursor
Secondary accessions
Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Domain

Bait regionSignal

PTM

Disulfide bondGlycoproteinIsopeptide bondThioester bond

Molecular function

Protease inhibitorSerine protease inhibitor

Cellular component

Secreted

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