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HMGB1 Antibody

CAT: 0800-F43873-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F43873-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V (D) J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) . Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity) . [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P09429
Host
Rabbit
Reactivity
Human
Immunogen
This HMGB1 antibody was produced from rabbits immunized with human HMGB1 recombinant protein.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HMGB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HMGB1 antibody is available for research use only.
Storage Conditions
Aliquot the HMGB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the HMGB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Primate
Image Legend
HMGB1 antibody western blot analysis in CEM lysate. Predicted molecular weight ~25 kDa.

UniProtKB · P09429

High mobility group protein B1

HMGB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09429
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HMGB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A5D8W9, Q14321, Q5T7C3, Q6IBE1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationDisulfide bondIsopeptide bondOxidationPhosphoprotein

Biological process

Adaptive immunityAutophagyChemotaxisDNA damageDNA recombinationDNA repairHost-virus interactionImmunityInflammatory responseInnate immunity

Cellular component

Cell membraneChromosomeCytoplasmEndoplasmic reticulumEndosomeMembraneNucleusSecreted

Molecular function

DNA-binding

Domain

Repeat

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