TRPM8 Antibody

CAT: 0800-F41609-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F41609-0.08MLSize:0.08 mL
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q7Z2W7
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 69-98 from the human protein was used as the immunogen for this TRPM8 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TRPM8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TRPM8 antibody is available for research use only.
Storage Conditions
Aliquot the TRPM8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TRPM8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
TRPM8 antibody immunohsitochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma.
Product Datasheet
Loading...

Alternative Products

Popular Products