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TRPM7 Antibody

CAT: 0800-F40171-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F40171-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q96QT4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 1821-1850 from the human protein was used as the immunogen for this TRPM7 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TRPM7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TRPM7 antibody is available for research use only.
Storage Conditions
Aliquot the TRPM7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TRPM7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of CHAK1 / TRPM7 antibody and mouse kidney tissue lysate.

UniProtKB · Q96QT4

Transient receptor potential cation channel subfamily M member 7

TRPM7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96QT4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TRPM7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2
Protein keywords

PTM

AcetylationLipoproteinPalmitatePhosphoprotein

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegenerationParkinsonism

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingZinc

Molecular function

Calcium channelIon channelKinaseSerine/threonine-protein kinaseTransferase

Biological process

Calcium transportIon transportNecrosisTransport

Cellular component

Cell membraneCytoplasmic vesicleMembraneNucleus

Domain

Coiled coilTransmembraneTransmembrane helix

Technical term

Proteomics identificationReference proteome

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