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TNFR1 Antibody

CAT: 0800-F41241-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F41241-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50
UniProt
P19438
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 252-281 from the human protein was used as the immunogen for this TNFR1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TNFR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TNFR1 antibody is available for research use only.
Storage Conditions
Aliquot the TNFR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TNFR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
TNFR1 antibody western blot analysis in A549 lysate. Predicted molecular weight ~51kDa.

UniProtKB · P19438

Tumor necrosis factor receptor superfamily member 1A

TNR1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19438
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K4X3, B2RDE4, B3KPQ1, B4DQB7, B4E309, B5M0B5, D3DUR1, Q9UCA4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

AmyloidosisDisease variant

Biological process

ApoptosisHost-virus interaction

Cellular component

Cell membraneGolgi apparatusMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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