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TNFR2 Antibody

CAT: 0800-R30345Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30345Size:100 µg
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Description
Tumor necrosis factor receptor 2 is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P20333
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human TNF Receptor 2 (DQVETQACTREQNRICTCR) was used as the immunogen for this TNFR2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the TNFR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TNFR2 antibody is available for research use only.
Storage Conditions
After reconstitution, the TNFR2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the TNFR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, membrane
Image Legend
Western blot testing of TNFR2 antibody and Lane 1: MM453; 2: Jurkat cell lysate. Predicted molecular weight: 50 kDa (unmodified), 70-80 kDa (glycosylated) .

UniProtKB · P20333

Tumor necrosis factor receptor superfamily member 1B

TNR1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20333
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B1AJZ3, Q16042, Q6YI29, Q9UIH1
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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