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BCL-6 Antibody

CAT: 0800-F40298-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F40298-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:250
UniProt
P41182
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 676-704 from the human protein was used as the immunogen for this BCL-6 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
305CT16.3.3
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the BCL-6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This BCL-6 antibody is available for research use only.
Storage Conditions
Aliquot the BCL-6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the BCL-6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
BCL-6 antibody western blot analysis in NCI-H292 lysate. Predicted molecular weight: 78~100 kDa.

UniProtKB · P41182

B-cell lymphoma 6 protein

BCL6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P41182
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BCL6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BCL-6
EC number
—
Processing
—
Secondary accessions
A7E241, B8PSA7, D3DNV5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ImmunityInflammatory responseTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Disease

Proto-oncogene

Domain

RepeatZinc-finger

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