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LIMK1 Antibody

CAT: 0800-F40237-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F40237-0.4MLSize:0.4 mL
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Description
Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.
CAS Number
9007-83-4
UniProt
P53667
Host
Mouse
Immunogen
A portion of amino acids 479-508 from the human protein was used as the immunogen for this LIMK1 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
WB, ELISA
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the LIMK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LIMK1 antibody is available for research use only.

UniProtKB · P53667

LIM domain kinase 1

LIMK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P53667
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LIMK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
LIMK-1
EC number
2.7.11.1
Processing
—
Secondary accessions
B7Z6I8, D3DXF4, D3DXF5, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Cellular component

Cell projectionCytoplasmCytoskeletonNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Domain

LIM domainRepeat

PTM

PhosphoproteinUbl conjugation

Disease

Williams-Beuren syndrome
Product Datasheet
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