LRP5 Antibody

CAT: 0800-F40130-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F40130-0.08MLSize:0.08 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
O75197
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 1538-1567 from the human protein was used as the immunogen for this LRP5 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the LRP5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LRP5 antibody is available for research use only.
Storage Conditions
Aliquot the LRP5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the LRP5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
LRP5 antibody used in western blot to detect recombinant human LRP5 (Lane 1) and mouse LRP5 (2) proteins in transfected 293 cell lysate; Data is kindly provided by Drs. V. Harris and S. Aaronson from the Mount Sinai School of Medicine

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