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CD91 Antibody / LRP1 / A2MR

CAT: 0800-V4301SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4301SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF) -like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and Alpha-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including Alpha-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q07954
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human LRP1 protein was used as the immunogen for the CD91 antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
LRP1/7152
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the CD91 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD91 antibody is available for research use only.
Storage Conditions
Aliquot the CD91 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CD91 antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus, Cell surface
Image Legend
IHC staining of FFPE human brain tissue with CD91 / LRP1 antibody (clone LRP1/7152) Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q07954

Prolow-density lipoprotein receptor-related protein 1

LRP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q07954
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LRP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
LRP-1
EC number
—
Processing
Precursor
Secondary accessions
Q2PP12, Q86SW0, Q8IVG8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Cellular component

Cell membraneCoated pitCytoplasmCytoskeletonGolgi apparatusMembraneNucleus

Molecular function

Developmental proteinReceptor

Disease

Disease variant

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Biological process

EndocytosisHost-virus interaction

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