C4B Antibody / Complement C4B

CAT: 0800-F40031-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F40031-0.08MLSize:0.08 mL
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Description
This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P0C0L4, P0C0L5
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 655-684 from the human protein was used as the immunogen for this C4B antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the C4B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This C4B antibody is available for research use only.
Storage Conditions
Aliquot the C4B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the C4B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human HepG2 cell lysate with C4B antibody. Predicted molecular weight ~193 kDa.
Product Datasheet
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