Anagrelide (hydrochloride) (Standard)

Anagrelide (hydrochloride) (Standard)

• CAS Number: 58579-51-4
• UNSPSC Description: Anagrelide (hydrochloride) (Standard) is the analytical standard of Anagrelide (hydrochloride). This product is intended for research and analytical applications. Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
• Target Antigen: Apoptosis; Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/anagrelide-hydrochloride-standard.html
• Smiles: ClC1=C(CN(C2)C3=NC2=O)C(N3)=CC=C1Cl.Cl
• Molecular Weight: 292.55
• References & Citations: [1]Pescatore, S.L. and C. Lindley, Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother, 2000. 1(3): p. 537-46.|[2]Petrides, P.E., Anagrelide: what was new in 2004 and 2005? Semin Thromb Hemost, 2006. 32(4 Pt 2): p. 399-408.
• Shipping Conditions: Room temperature