Anagrelide (hydrochloride)
CAT:
804-HY-B0523A-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anagrelide (hydrochloride)
- CAS Number: 58579-51-4
- UNSPSC Description: Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
- Target Antigen: Apoptosis; Phosphodiesterase (PDE)
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Cancer; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/Anagrelide-hydrochloride.html
- Purity: 99.66
- Solubility: DMSO : 6.36 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: ClC1=C(CN(C2)C3=NC2=O)C(N3)=CC=C1Cl.Cl
- Molecular Weight: 292.55
- References & Citations: [1]Pescatore, S.L. and C. Lindley, Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother, 2000. 1(3): p. 537-46.|[2]Petrides, P.E., Anagrelide: what was new in 2004 and 2005? Semin Thromb Hemost, 2006. 32(4 Pt 2): p. 399-408.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched