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Nesolicaftor

CAT: 0804-HY-111680-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111680-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier[1].
CAS Number
1953130-87-4
Product Name Alternative
PTI-428
UNSPSC
12352005
Target
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/PTI-428.html
Purity
99.37
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2=CC=CC=C2)=NO1)N[C@H]3C[C@H](C4=NN=C([C@H](O)C)O4)C3
Molecular Formula
C18H18N4O4
Molecular Weight
354.36
References & Citations
[1]Mijnders M, et al. Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis. Curr Opin Pharmacol. 2017 Jun;34:83-90.|[2]Arianna Venturini, et al. Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene. Int J Mol Sci. 2021 Nov 4;22 (21) :11972.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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BUP09263-01Nesolicaftor
C17876Nesolicaftor (PTI-428)

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