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Antibacterial agent 256

CAT: 0804-HY-168729Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168729Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I) . Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model[1].
CAS Number
3052804-28-8
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antibacterial-agent-256.html
Smiles
CC(C1)C/C(C2=C1C(C(O)=O)=C(C=CC=C3)C3=N2)=C\C4=CC=C(C5=CC=C(Cl)C(C(F)(F)F)=C5)S4
Molecular Formula
C27H19ClF3NO2S
Molecular Weight
513.96
References & Citations
[1]Lu X, et al., Discovery and optimization of tetrahydroacridine derivatives as a novel class of antibiotics against multidrug-resistant Gram-positive pathogens by targeting type I signal peptidase and disrupting bacterial membrane. Eur J Med Chem. 2024 Nov 26;283:117101.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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