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α7 nAChR Modulator-3

CAT: 0804-HY-157958Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157958Size:1 Each
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Description
α7 nAChR modulator-3 (Compound 6p) is a α7 nAChR positive allosteric Modulator with a IC50 value of 1.3 μM. α7 nAChR Modulator-3 can be used to inhibit auditory gating defects in a mouse schizophrenic model[1].
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α7-nachr-modulator-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N=C(S1)NC2=CC(Cl)=C(C=C2)F)N)NC3=C(C=CC=C3C)Cl
Molecular Formula
C17H13Cl2FN4OS
Molecular Weight
411.28
References & Citations
[1]Yang C, et al. Allosteric Activation of α7 Nicotinic Acetylcholine Receptors by Novel 2-Arylamino-thiazole-5-carboxylic Acid Amide Derivatives for the Improvement of Cognitive Deficits in Mice. J Med Chem. 2024 Feb 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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